Pharmaceuticals

Moisture and organic vapor can affect the solid state. This may be due to the formation of a hydrate phase or an induced amorphous-to-crystalline phase transition. These moisture-induced phase changes can affect mechanical properties, cause chemical interactions and alter yield, purity and dosage calculations.

The IGAsorp uses the DVS technique (Dynamic Vapor Sorption) and is designed to characterize interactions with pharmaceuticals including water sorption isotherms, surface area and porosity, amorphous phase content, Hydration analysis, and the measure kinetics such as diffusion coefficeints and Moisture Vapor Transmission Rates (MVTRs).

We are also specialists in the measurement of interactions with less common species including, for example, the interactions of propellant pressurised gases with powders and thermal desorption analyses by dynamic sampling mass spectrometry.

The IGAsorp is firmly established as a market leader and is used in many high profile academic, R&D and manufacturing environments worldwide.

Example Measurements
  • Detect and quantify amorphous phases
  • Measure kinetics such as diffusion rates and MVTRs (moisture vapor transition rates)
  • Characterize water and vapor sortion isotherms
  • Investigating hydrate phases and deliquescence
  • Vapor permeation
  • Interaction of propellant pressurised gases with powders
Resources & Downloads
  • Dynamic vapour sorption (DVS) characterisation and MVTR properties in pharmaceutical materials

  • Moisture Sorption Analysis of Aspirin

  • An Equilibrium and Kinetic Sorption Study of the Interaction of Amorphous Trehalose with Water Vapour

Related Instruments

Fully automated compact bench-top DVS analyzer, For fast and accurate sorption measurements

Fully automated DVS analyzer, with advanced control method for water sorption under extreme conditions

Single Component Gravimetric Analyzer, for Precise Characterization of Gas and Vapor Sorption Equilibria and Kinetics

Any Questions? Get In Touch

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Call us on +44 (0) 1925 244678 or click below to contact us.